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BDBM252468 US9458172, 39

SMILES: O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)c1cc2ccncc2s1

InChI Key: InChIKey=BFNKHPBJZVQMKB-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 252468   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252468
PNG
(US9458172, 39)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)c1cc2ccncc2s1
Show InChI InChI=1S/C24H22N4O4S2/c29-24(22-13-17-7-8-25-16-23(17)33-22)27-14-18-1-4-21(15-26-18)34(30,31)20-5-2-19(3-6-20)28-9-11-32-12-10-28/h1-8,13,15-16H,9-12,14H2,(H,27,29)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.80n/an/an/an/a7.5n/a



TBA

US Patent


Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


US Patent US9458172 (2016)


BindingDB Entry DOI: 10.7270/Q2TB15V5
More data for this
Ligand-Target Pair