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BDBM252469 US9458172, 40

SMILES: Cn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)nc1

InChI Key: InChIKey=IKTPCCNVCKLLJL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 252469   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252469
PNG
(US9458172, 40)
Show SMILES Cn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)nc1
Show InChI InChI=1S/C18H15N5O3S2/c1-23-11-15(9-22-23)28(25,26)14-3-2-13(20-8-14)7-21-18(24)16-6-12-4-5-19-10-17(12)27-16/h2-6,8-11H,7H2,1H3,(H,21,24)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 134n/an/an/an/a7.5n/a



TBA

US Patent


Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


US Patent US9458172 (2016)


BindingDB Entry DOI: 10.7270/Q2TB15V5
More data for this
Ligand-Target Pair