BDBM25373 (R)-(hydroxyethylamino)sulfonamide isostere, 3j::1,4,7,10-tetraoxacyclotridecan-12-yl N-[(2S,3R)-3-hydroxy-4-[(4-methoxybenzene)(2-methylpropyl)sulfonamido]-1-phenylbutan-2-yl]carbamate::US8501961, 24::US8501961, 3j

SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC1COCCOCCOCCOC1

InChI Key InChIKey=GIMVBMLYXOBVGH-XZWHSSHBSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 25373   

TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Purdue Research Foundation

US Patent
LigandPNGBDBM25373((R)-(hydroxyethylamino)sulfonamide isostere, 3j | ...)
Affinity DataKi:  33nMAssay Description:Enzyme inhibitory assay utilizes a protocol described by Toth and Marshall (Toth, M. V.; Marshall G.R. A simple, continuous fluormetric assay for HIV...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM25373((R)-(hydroxyethylamino)sulfonamide isostere, 3j | ...)
Affinity DataKi:  33nM ΔG°:  -10.2kcal/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed