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BDBM254523 US9468661, 101

SMILES: CC1(C)[C@@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3ccncc23)C1(Cl)Cl

InChI Key: InChIKey=JIZAPLGGCXILKD-IKVITTDRSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 254523   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor D


(Homo sapiens (Human))
BDBM254523
PNG
(US9468661, 101)
Show SMILES CC1(C)[C@@H](CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3ccncc23)C1(Cl)Cl
Show InChI InChI=1S/C21H24Cl2N6O3/c1-20(2)15(21(20,22)23)8-26-19(32)13-6-10-5-12(10)29(13)16(30)9-28-14-7-25-4-3-11(14)17(27-28)18(24)31/h3-4,7,10,12-13,15H,5-6,8-9H2,1-2H3,(H2,24,31)(H,26,32)/t10-,12-,13+,15-/m1/s1
PDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 297n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


US Patent US9468661 (2016)


BindingDB Entry DOI: 10.7270/Q23N22B5
More data for this
Ligand-Target Pair