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BDBM25593 2,6-Disubstituted Pyrazine, 56::6-(isoquinolin-5-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine

SMILES: COc1cc(Nc2cncc(Oc3cccc4cnccc34)n2)cc(OC)c1OC

InChI Key: InChIKey=IZPBCBBLTMSWLG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25593   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
B-RAF V600E


(Homo sapiens (Human))
BDBM25593
PNG
(2,6-Disubstituted Pyrazine, 56 | 6-(isoquinolin-5-...)
Show SMILES COc1cc(Nc2cncc(Oc3cccc4cnccc34)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H20N4O4/c1-27-18-9-15(10-19(28-2)22(18)29-3)25-20-12-24-13-21(26-20)30-17-6-4-5-14-11-23-8-7-16(14)17/h4-13H,1-3H3,(H,25,26)
PDB

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PC cid
PC sid
UniChem

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Similars

Article
PubMed
n/an/a 3.80E+3n/an/an/an/an/an/a



Cancer Research UK Centre for Cancer Therapeutics



Assay Description
BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...


J Med Chem 51: 3261-74 (2008)


Article DOI: 10.1021/jm070776b
BindingDB Entry DOI: 10.7270/Q2X34VRR
More data for this
Ligand-Target Pair