BindingDB logo
myBDB logout

BDBM255942 US9481672, 120

SMILES: CCOC(=O)c1cn(-c2ccc3n(C)c(=O)n(C)c3c2)c(=O)n(C2CCc3cc(OC)ccc23)c1=O

InChI Key: InChIKey=YCSBXUSCJHWSKQ-UHFFFAOYNA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 255942   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Mesocricetus auratus (Golden hamster))
BDBM255942
PNG
(US9481672, 120)
Show SMILES CCOC(=O)c1cn(-c2ccc3n(C)c(=O)n(C)c3c2)c(=O)n(C2CCc3cc(OC)ccc23)c1=O
Show InChI InChI=1/C26H26N4O6/c1-5-36-24(32)19-14-29(16-7-11-21-22(13-16)28(3)25(33)27(21)2)26(34)30(23(19)31)20-10-6-15-12-17(35-4)8-9-18(15)20/h7-9,11-14,20H,5-6,10H2,1-4H3
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/a7.5n/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...


US Patent US9481672 (2016)


BindingDB Entry DOI: 10.7270/Q20P0XZ7
More data for this
Ligand-Target Pair