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BDBM256863 US9492453, 51

SMILES: NC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)N[C@@H](CCN1CCOCC1)c1ccc(Cl)cc1

InChI Key: InChIKey=UYOGLMREZZLOIK-RNZRUAGMNA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 256863   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM256863
PNG
(US9492453, 51)
Show SMILES NC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)N[C@@H](CCN1CCOCC1)c1ccc(Cl)cc1
Show InChI InChI=1/C25H32ClN7O2/c26-19-3-1-18(2-4-19)21(6-10-32-13-15-35-16-14-32)31-24(34)25(27)7-11-33(12-8-25)23-20-5-9-28-22(20)29-17-30-23/h1-5,9,17,21H,6-8,10-16,27H2,(H,31,34)(H,28,29,30)/t21-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/a7.525



AstraZeneca AB

US Patent


Assay Description
This assay detects inhibitors of AKT1 (PKBα) kinase activity using Caliper LabChip LC3000. The Caliper off-chip incubation mobility shift assay...


US Patent US9492453 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M83
More data for this
Ligand-Target Pair