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BDBM256870 US9492453, 66

SMILES: NC(=O)CC(NC(=O)C1(N)CCN(CC1)c1ncnc2[nH]ccc12)c1ccc(Cl)cc1

InChI Key: InChIKey=MXJXTTUATUMZSQ-UHFFFAOYNA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 256870   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM256870
PNG
(US9492453, 66)
Show SMILES NC(=O)CC(NC(=O)C1(N)CCN(CC1)c1ncnc2[nH]ccc12)c1ccc(Cl)cc1
Show InChI InChI=1/C21H24ClN7O2/c22-14-3-1-13(2-4-14)16(11-17(23)30)28-20(31)21(24)6-9-29(10-7-21)19-15-5-8-25-18(15)26-12-27-19/h1-5,8,12,16H,6-7,9-11,24H2,(H2,23,30)(H,28,31)(H,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.60n/an/an/an/a7.525



AstraZeneca AB

US Patent


Assay Description
This assay detects inhibitors of AKT1 (PKBα) kinase activity using Caliper LabChip LC3000. The Caliper off-chip incubation mobility shift assay...


US Patent US9492453 (2016)


BindingDB Entry DOI: 10.7270/Q2KH0M83
More data for this
Ligand-Target Pair