BDBM25725 1,3-diphenylurea::Urea-based compound, 7

SMILES O=C(Nc1ccccc1)Nc1ccccc1

InChI Key InChIKey=GWEHVDNNLFDJLR-UHFFFAOYSA-N

Data  6 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25725   

TargetEpoxide hydrolase B(Mycobacterium tuberculosis)
University Of Alberta

LigandPNGBDBM25725(1,3-diphenylurea | Urea-based compound, 7)
Affinity DataIC50:  19nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM25725(1,3-diphenylurea | Urea-based compound, 7)
Affinity DataIC50: >6.60E+5nMAssay Description:Inhibition of SYK expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Homo sapiens (Human))TBA
LigandPNGBDBM25725(1,3-diphenylurea | Urea-based compound, 7)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of microsomal epoxide hydrolase (unknown origin) using 7-(2-(Oxiran-2- yl)ethoxy) Resorufin by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM25725(1,3-diphenylurea | Urea-based compound, 7)
Affinity DataIC50:  390nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM25725(1,3-diphenylurea | Urea-based compound, 7)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonat...More data for this Ligand-Target Pair
TargetEpoxide hydrolase B(Mycobacterium tuberculosis)
University Of Alberta

LigandPNGBDBM25725(1,3-diphenylurea | Urea-based compound, 7)
Affinity DataIC50:  19nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant EphB expressed in Escherichia coli BL21 using CMNPC as substrate after 30 mins by fluorescent as...More data for this Ligand-Target Pair