BDBM25730 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea::US10383835, Compound 295::US8815951, 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea::Urea-based compound, 11::cid_7547

SMILES Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1

InChI Key InChIKey=ICUTUKXCWQYESQ-UHFFFAOYSA-N

Data  12 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 25730   

TargetEpoxide hydrolase B(Mycobacterium tuberculosis)
University Of Alberta

LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  220nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  1.49E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  805nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEpoxide hydrolase 1(Mus musculus (Mouse))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  360nMAssay Description:The invention also provide methods for assaying for epoxide hydrolase activity as diagnostic assay to identify individuals at increased risk for hype...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase 1(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  120nMAssay Description:The invention also provide methods for assaying for epoxide hydrolase activity as diagnostic assay to identify individuals at increased risk for hype...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase 1(Canis lupus familiaris (Dog) (Canis familiaris))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  5.20E+3nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase(Equus caballus (Horse))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  267nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase(Ovis aries (Sheep))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  56nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Sus scrofa (Pig))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  61nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase 1(Felis catus (Cat) (Felis silvestris catus))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  680nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase B(Mycobacterium tuberculosis)
University Of Alberta

LigandPNGBDBM25730(3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea | US...)
Affinity DataIC50:  220nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant EphB expressed in Escherichia coli BL21 using CMNPC as substrate after 30 mins by fluorescent as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed