BDBM25745 3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluoromethoxy)phenyl]urea::US10383835, Compound 1709::US9296693, 55::Urea-based compound, 26

SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=YORLNOBDSZJFQQ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 25745   

TargetEpoxide hydrolase B(Mycobacterium tuberculosis)
University Of Alberta

LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  2.79E+4nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  2.90nMpH: 7.0Assay Description:IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  2nMpH: 7.0Assay Description:IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  2nMAssay Description:Inhibition of mouse recombinant soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Canis lupus familiaris (Dog) (Canis familiaris))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  3.20E+3nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase(Equus caballus (Horse))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  59nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase(Ovis aries (Sheep))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  30nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Sus scrofa (Pig))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  60nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpoxide hydrolase 1(Felis catus (Cat) (Felis silvestris catus))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  565nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM25745(3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluor...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed