BDBM257707 US9493446, 176

SMILES: Cc1cc(F)cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c1-n1nccn1

InChI Key: InChIKey=QWIHDXNUIKISCS-KRWDZBQOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 257707   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM257707 (US9493446, 176) Show SMILES Cc1cc(F)cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c1-n1nccn1 Show InChI InChI=1S/C23H18F4N6O3/c1-13-11-14(24)12-16(19(13)33-28-8-9-29-33)22(34)32-10-4-6-17(32)21-30-20(31-36-21)15-5-2-3-7-18(15)35-23(25,26)27/h2-3,5,7-9,11-12,17H,4,6,10H2,1H3/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	37
Actelion Pharmaceuticals Ltd US Patent					Assay Description Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...				US Patent US9493446 (2016) BindingDB Entry DOI: 10.7270/Q2DR2TD0
					More data for this Ligand-Target Pair
Orexin receptor type 1 (Homo sapiens (Human))	BDBM257707 (US9493446, 176) Show SMILES Cc1cc(F)cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c1-n1nccn1 Show InChI InChI=1S/C23H18F4N6O3/c1-13-11-14(24)12-16(19(13)33-28-8-9-29-33)22(34)32-10-4-6-17(32)21-30-20(31-36-21)15-5-2-3-7-18(15)35-23(25,26)27/h2-3,5,7-9,11-12,17H,4,6,10H2,1H3/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	258	n/a	n/a	n/a	n/a	n/a	37
Actelion Pharmaceuticals Ltd US Patent					Assay Description Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...				US Patent US9493446 (2016) BindingDB Entry DOI: 10.7270/Q2DR2TD0
					More data for this Ligand-Target Pair