BDBM2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US11958831, Example Staurosporine::US20240002365, Compound staurosporine::US20240254124, Compound Staurosporine::US20240309004, Compound STAUROSPORINE::US9206188, Staurosporine::US9226923, Staurosporine

SMILES: C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC

InChI Key: InChIKey=HKSZLNNOFSGOKW-UHFFFAOYSA-N

Data: 14 KI  1496 IC50  886 Kd  1 EC50  1 ITC

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2449 hits for monomerid = 2579   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C beta type (Rat)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	30
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Protein kinase C beta type (Rat)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
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cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	121	n/a	n/a	n/a	n/a	8.5	37
TBA									Citation and Details
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Myosin light chain kinase, smooth muscle (Chicken)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein kinase C beta type (Rat)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cGMP-dependent protein kinase 1 (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein phosphatase non-receptor type 2 (Mouse)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Myosin light chain kinase, smooth muscle (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Blk (Mouse)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	7.0	22
TBA									Citation and Details
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Serine/threonine-protein kinase pim-1 (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	7.6	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<45	n/a	n/a	n/a	n/a	6.8	25
TBA									Citation and Details
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cAMP-dependent protein kinase catalytic subunit alpha [L49I] (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	47	n/a	n/a	n/a	n/a	6.8	25
TBA									Citation and Details
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cAMP-dependent protein kinase catalytic subunit alpha [V123M] (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<45	n/a	n/a	n/a	n/a	6.8	25
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cAMP-dependent protein kinase catalytic subunit alpha [T183A] (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<45	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha [E127D] (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<45	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-dependent protein kinase catalytic subunit alpha [Q181K,T183A] (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<45	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [L49I,Q181K,T183A] (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<45	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha [V123M,Q181K,T183A] (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<45	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,Q181K,T183A] (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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cAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,E127D,Q181K,T183A] (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<45	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Rho-associated protein kinase 2 (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D] (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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RAC-beta serine/threonine-protein kinase (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.5	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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RAC-gamma serine/threonine-protein kinase (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
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Protein kinase C gamma type (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.60	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
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Protein kinase C zeta type (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	570	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.00E+3	290	n/a	n/a	n/a	7.2	20
TBA									Citation and Details
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3-phosphoinositide-dependent protein kinase 1 [51-359] (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.5	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
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Macrophage colony-stimulating factor 1 receptor [538-972] ()	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	57	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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Macrophage colony-stimulating factor 1 receptor [538-678,753-922] (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	49	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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Macrophage colony-stimulating factor 1 receptor [538-678,753-922] (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	57	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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Serine/threonine-protein kinase Chk2 [209-531,Q209M] (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	80	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
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Calcium-dependent protein kinase 1 (Plasmodium Falciparum)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	240	n/a	n/a	n/a	n/a	7.5	24
TBA									Citation and Details
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Activin receptor type-1 (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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TGF-beta receptor type-1 (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
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5'-AMP-activated protein kinase subunit beta-1/5'-AMP-activated protein kinase subunit gamma-1/Dual specificity protein kinase CLK2 (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.29	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.14	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Chicken)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.30	8	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase CSK (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
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Glycogen synthase kinase-3 beta (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Glycogen synthase kinase-3 beta (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	30
TBA									Citation and Details
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Glycogen synthase kinase-3 beta (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK1 (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK2 (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase JAK3 (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ITK/TSK (Human)	BDBM2579 (CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.02	n/a	n/a	n/a	n/a	n/a	n/a
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