BindingDB PrimarySearch

BDBM25817 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol::CHEMBL106::Diflucan::Fluconazole::Fluconazole (f)::Fungata::Triflucan::US10221160, Fluconazole::US11247981, Example Fluconazole::US9138393, Fluconazole::US9144538, Fluconazole::US9221791, Fluconazole::US9556143, Fluconazole::cid_3365

SMILES: c1cc(c(cc1F)F)C(Cn2cncn2)(Cn3cncn3)O

InChI Key: InChIKey=RFHAOTPXVQNOHP-UHFFFAOYSA-N

Data: 4 KI 51 IC50 12 Kd 1 EC50

PDB links: 17 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 69 hits for monomerid = 25817
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cytochrome P450 3A4 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Yeast)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Yeast)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Yeast)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Yeast)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Yeast)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.89E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Yeast)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Yeast)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Yeast)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
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Histone deacetylase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
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Sterol 14-alpha demethylase (Trypanosoma cruzi (strain CL Brener))	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
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Aromatase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Steroid 17-alpha-hydroxylase/17,20 lyase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 11B2, mitochondrial (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Steroid 17-alpha-hydroxylase/17,20 lyase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
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Mycocyclosin synthase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a
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Sterol 14-alpha demethylase cyp51A (Neosartorya fumigata (Aspergillus fumigatus))	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14a-demethylase (Neosartorya fumigata)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.03E+3	n/a	n/a	n/a	n/a	n/a
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Malate dehydrogenase, cytoplasmic (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-lactamase (Escherichia coli (strain K12))	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Chymotrypsinogen A (Bovine)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha demethylase (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
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Heme oxygenase 2 (Rat)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.4	37
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Cytochrome P450 3A4 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Steroid C26-monooxygenase (Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	8.60E+5	n/a	n/a	n/a	n/a	n/a
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Steroid C26-monooxygenase (Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.31E+4	n/a	n/a	n/a	n/a	n/a
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Lanosterol 14-alpha-demethylase (Trypanosoma brucei brucei (strain 927/4 GUTat10.1))	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	340	n/a	n/a	n/a	6.0	n/a
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Sterol 14-alpha demethylase (Trypanosoma cruzi (strain CL Brener))	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	230	n/a	n/a	n/a	6.0	n/a
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Bcl-2-like protein 11 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	>3.50E+5	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Heme oxygenase 1 (Rat)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	7.4	37
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Lanosterol 14-alpha demethylase (Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	7.5	37
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Cytochrome P450 3A4 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM25817 (Fungata \| Diflucan \| Fluconazole (f) \| cid_3365 \| ...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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