BDBM2583 3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione::3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::BIM-4::Bisindolyl deriv. 3::Bisindolylmaleimide deriv. 5::CHEMBL266487::bis-indolylmaleimide deriv. 8a

SMILES: O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12

InChI Key: InChIKey=DQYBRTASHMYDJG-UHFFFAOYSA-N

Data: 19 IC50  1 Kd  1 ITC

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 2583   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1/ABL2 (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase pim-1 (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a
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Calcium/calmodulin-dependent protein kinase type II subunit delta (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C epsilon type (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C beta type (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	304	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C alpha type (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C beta type (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	212	n/a	n/a	n/a	n/a	n/a	n/a
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NAD-dependent protein deacetylase sirtuin-2 (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Protein kinase C beta type (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C beta type (Rat)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	550	n/a	n/a	n/a	n/a	7.5	30
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cAMP-dependent protein kinase (Rabbit)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	25
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.17E+4	n/a	n/a	n/a	n/a	n/a	25
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.81E+3	n/a	n/a	n/a	n/a	7.0	22
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Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Rabbit)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Rat)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	7.4	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a	8.5	37
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Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 2583

Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kcal/mole	-TΔS° kcal/mole	ΔH° kcal/mole	log K	pH	Temp °C
BDBM2583 (bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...)	Serine/threonine-protein kinase PIM (Human)		GoogleScholar		-9.78	0.548	-10.4	7.57	7.5	10
	TBA				Details of this binding reaction