BDBM25900 2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide::Chlortalidone::Chlorthalidone::Chlorthalidone (1)::Hygroton::Phthalamudine::US10172837, Chlorthalidone

SMILES: c1ccc2c(c1)C(=O)N[C@@]2(c3ccc(c(c3)S(=O)(=O)N)Cl)O

InChI Key: InChIKey=JIVPVXMEBJLZRO-UHFFFAOYSA-N

Data: 16 KI  5 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 25900   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bile salt export pump (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 4 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 3 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 7 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		4.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 5B, mitochondrial (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 13 (Mouse)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		138	-9.35	n/a	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		196	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		348	-8.80	n/a	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 5A, mitochondrial (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		917	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 6 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 14 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		4.13E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		4.50E+3	-7.29	n/a	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 3 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		1.10E+4	-6.76	n/a	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		2.30E+4	-6.32	n/a	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		1.38E+5	-5.26	n/a	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM25900 (Hygroton | Chlortalidone | 2-chloro-5-(1-hydroxy-3...) Show SMILES Show InChI	GoogleScholar	UniChem		3.48E+5	-4.71	n/a	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair