BDBM25902 4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid::CHEMBL35::Frusemide::Furanthril::Furosemide::Furosemide (3)::Furosemide, 4::Lasix::US10172837, Furosemide

SMILES: c1cc(oc1)CNc2cc(c(cc2C(=O)O)S(=O)(=O)N)Cl

InChI Key: InChIKey=ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Data: 26 KI  23 IC50  1 Kd  2 EC50

PDB links: 8 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 25902   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mouse)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 2 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 4 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 1 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
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Holo-[acyl-carrier-protein] synthase (Bacillus subtilis (strain 168))	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Aquaporin-4 (Rat)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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CDGSH iron-sulfur domain-containing protein 1 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.02E+5	n/a	n/a	n/a	n/a	n/a	n/a
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CDGSH iron-sulfur domain-containing protein 1 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.30E+4	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 3 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.14E+3	n/a	n/a	n/a	n/a	n/a
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11-beta-hydroxysteroid dehydrogenase 1 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Broad substrate specificity ATP-binding cassette transporter ABCG2 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium/bile acid cotransporter (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Multidrug and toxin extrusion protein 1 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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G-protein coupled receptor 35 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a
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G-protein coupled receptor 35 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a
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Bile salt export pump (Rat)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2J2 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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CDGSH iron-sulfur domain-containing protein 1 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 3 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Bile salt export pump (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>9.65E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 14 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 1 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		62	-9.83	n/a	n/a	n/a	n/a	n/a	7.4	25
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Carbonic anhydrase 2 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		65	-9.80	n/a	n/a	n/a	n/a	n/a	7.4	25
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Carbonic anhydrase 6 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		245	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 12 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		261	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 5B, mitochondrial (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		322	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 9 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 5A, mitochondrial (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		499	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 7 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		513	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 13 (Mouse)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 4 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		564	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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CDGSH iron-sulfur domain-containing protein 1 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		2.29E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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G-protein coupled receptor 35 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		3.27E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 6 (Rat)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier organic anion transporter family member 2A1 (Rat)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		4.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 1 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		6.20E+4	-5.74	n/a	n/a	n/a	n/a	n/a	7.5	25
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Carbonic anhydrase 2 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		6.50E+4	-5.71	n/a	n/a	n/a	n/a	n/a	7.5	25
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Adenosine receptor A2a/A2b (Rat)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Adenosine receptor A1 (Guinea pig)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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6-phosphogluconate dehydrogenase, decarboxylating (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		1.27E+5	n/a	1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Albumin (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Glucose-6-phosphate 1-dehydrogenase (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		1.87E+5	n/a	3.15E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 3 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+5	>-5.04	n/a	n/a	n/a	n/a	n/a	7.4	25
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Carbonic anhydrase 12 (Human)	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES Show InChI	GoogleScholar	UniChem		2.61E+5	-4.89	n/a	n/a	n/a	n/a	n/a	7.5	25
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