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BDBM2593 (Arylindolyl)maleimide deriv. 15::3-(1-methyl-1H-indol-3-yl)-4-(1-propyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::ROCHE screening, 42

SMILES: CCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12

InChI Key: InChIKey=NMPSBQCWPUSRMH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2593   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM2593
PNG
((Arylindolyl)maleimide deriv. 15 | 3-(1-methyl-1H-...)
Show SMILES CCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H21N3O2/c1-3-12-27-14-18(16-9-5-7-11-20(16)27)22-21(23(28)25-24(22)29)17-13-26(2)19-10-6-4-8-15(17)19/h4-11,13-14H,3,12H2,1-2H3,(H,25,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.97E+3n/an/an/an/an/an/a



Technical University of Dortmund



Assay Description
IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...


ACS Chem Biol 10: 289-98 (2015)


Article DOI: 10.1021/cb500908d
BindingDB Entry DOI: 10.7270/Q2WH2NRB
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2593
PNG
((Arylindolyl)maleimide deriv. 15 | 3-(1-methyl-1H-...)
Show SMILES CCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H21N3O2/c1-3-12-27-14-18(16-9-5-7-11-20(16)27)22-21(23(28)25-24(22)29)17-13-26(2)19-10-6-4-8-15(17)19/h4-11,13-14H,3,12H2,1-2H3,(H,25,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 480n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair