BDBM259450 US9512114, 9::US9657007, Example 9

SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=HJAUKGHNPOFPSW-ZDUSSCGKSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 259450   

LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50:  2.68E+3nMT: 2°CAssay Description:PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50:  226nMT: 2°CAssay Description:PI3K (p1103/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as requ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50:  4nMT: 2°CAssay Description:PI3K (p110δ/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50:  255nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50:  2.68E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50:  226nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50:  4nMAssay Description:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50:  255nMT: 2°CAssay Description:PI3K (p120γ) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as required)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent