BDBM26105 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine::AEE788

SMILES: CCN1CCN(Cc2ccc(cc2)-c2cc3c(N[C@H](C)c4ccccc4)ncnc3[nH]2)CC1

InChI Key: InChIKey=OONFNUWBHFSNBT-UHFFFAOYSA-N

Data: 6 IC50  7 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 26105   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	10.9	n/a	n/a	n/a	7.4	22
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Epidermal growth factor receptor [696-1022,G719S] (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	11.3	n/a	n/a	n/a	7.4	22
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Epidermal growth factor receptor [696-1022,L858R] (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.70	n/a	n/a	n/a	7.4	22
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Epidermal growth factor receptor (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.30	n/a	n/a	n/a	7.4	22
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Epidermal growth factor receptor [696-1022,T790M] (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	27.6	n/a	n/a	n/a	7.4	22
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Epidermal growth factor receptor [696-1022,L858R] (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10	n/a	n/a	n/a	7.4	22
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Epidermal growth factor receptor [696-1022,T790M,L858R] (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	18.6	n/a	n/a	n/a	7.4	22
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Tyrosine-protein kinase Yes (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Yes (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 1 (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
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