BDBM26140 1-benzofuran-2-ylboranediol::1-benzofuran-2-ylboronic acid, 19::CHEMBL143399::Phenylboronic acid, 21
InChI string: InChI=1S/C8H7BO3/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H
SMILES: OB(O)c1cc2ccccc2o1
InChI Key: InChIKey=PKRRNTJIHGOMRC-UHFFFAOYSA-N
Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-lactamase AmpC (Escherichia coli) | BDBM26140![]() (1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Medical School Curated by ChEMBL | Assay Description Inhibitory activity against E. coli AmpC beta-lactamase. | J Med Chem 41: 4577-86 (1998) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Anandamide amidohydrolase (Rattus norvegicus (rat)) | BDBM26140![]() (1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | 7.4 | 37 |
University of Oxford | Assay Description [3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase... | J Med Chem 51: 7057-60 (2008) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 1 (Homo sapiens (Human)) | BDBM26140![]() (1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | n/a | n/a | 1.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase AmpC (Escherichia coli) | BDBM26140![]() (1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Medical School Curated by ChEMBL | Assay Description Compound was tested for its specificity against AmpC beta-lactamase | J Med Chem 41: 4577-86 (1998) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-chymotrypsin (Bos taurus (bovine)) | BDBM26140![]() (1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Medical School Curated by ChEMBL | Assay Description Compound was tested for its specificity against alpha-chymotrypsin | J Med Chem 41: 4577-86 (1998) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin (Homo sapiens) | BDBM26140![]() (1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Medical School Curated by ChEMBL | Assay Description Compound was tested for its specificity against beta-trypsin | J Med Chem 41: 4577-86 (1998) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoglyceride Lipase (MGL) (Homo sapiens (human)) | BDBM26140![]() (1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford | Assay Description The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ... | J Med Chem 51: 7057-60 (2008) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM26140![]() (1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents AffyNet ![]() | Article PubMed | n/a | n/a | 1.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) | |||||||||||
More data for this Ligand-Target Pair |