BDBM26198 4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11.4.0.0^{2,6}.0^{7,12}]heptadeca-1(13),2(6),3,7(12),8,14,16-heptaen-11-one::CHEMBL21156::Compound # 2::Jak Inhibitor 1::PDK1 inhibitor, 1::Tetracyclic Pyridone, 1

SMILES: CC(C)(C)c1nc2c([nH]1)c1ccc(F)cc1c1c2cc[nH]c1=O

InChI Key: InChIKey=VNDWQCSOSCCWIP-UHFFFAOYSA-N

Data: 35 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 26198   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 11/12/13/14 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 1 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity mitogen-activated protein kinase kinase 1/2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha/beta (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1/2/3/4 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK1 (Mouse)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 1/3 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	30
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Tyrosine-protein kinase JAK1 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	7.5	30
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Tyrosine-protein kinase JAK2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.5	n/a	n/a	n/a	n/a	7.5	30
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Tyrosine-protein kinase JAK3 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	7.5	30
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3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
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3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
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RAC-alpha serine/threonine-protein kinase (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 3 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	22
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Protein kinase C alpha type (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase CSK (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase HCK (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Mouse)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 2 (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	940	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM26198 (Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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