BDBM262154 2-(2H-tetrazol-5-yl)-4'-(2H-1,2,3- triazol-2-yl)biphenyl-3- sulfonamide::US9708336, 5

SMILES Cc1nc2ccccc2n1Cc1ccc(cc1)B1OC(C)(C)C(C)(C)O1

InChI Key InChIKey=YZEPCJMVEZJYEG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262154   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262154(2-(2H-tetrazol-5-yl)-4'-(2H-1,2,3- triazol-2-yl)bi...)
Affinity DataIC50: 3.44nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262154(2-(2H-tetrazol-5-yl)-4'-(2H-1,2,3- triazol-2-yl)bi...)
Affinity DataIC50: 56.5nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262154(2-(2H-tetrazol-5-yl)-4'-(2H-1,2,3- triazol-2-yl)bi...)
Affinity DataIC50: 72.3nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent