BDBM26263 Anexate::CHEMBL407::FLUMAZENIL::Ro15-1788::Romazicon::[3H]Ro15-1788::ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate

SMILES: CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21

InChI Key: InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N

Data: 77 KI  9 IC50  1 Kd  3 Other

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 90 hits for monomerid = 26263   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-binding cassette sub-family C member 4 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 3 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,F116C] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [Y209C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>7.34E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [D97C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [G157C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.190	-13.3	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
GABA-A receptor; alpha-5/beta-3/gamma-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
GABA-A receptor; alpha-5/beta-3/gamma-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.720	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.810	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.870	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
GABA-A receptor; alpha-2/beta-3/gamma-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
GABA-A receptor; alpha-2/beta-3/gamma-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [V202C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	-12.0	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Rat)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		2	-11.7	n/a	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [T206C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.10	-11.8	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [T162C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.20	-11.8	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [G200C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		3	-11.6	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,D95C] (Human)	BDBM26263 (ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...) Show SMILES Show InChI	GoogleScholar	UniChem		3.10	-11.6	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair