BDBM26269 3,5-dichloro-2-hydroxybenzoic acid::3,5-dichlorosalicylic acid::CHEMBL449129

SMILES OC(=O)c1cc(Cl)cc(Cl)c1O

InChI Key InChIKey=CNJGWCQEGROXEE-UHFFFAOYSA-N

Data  12 KI  2 IC50

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 26269   

TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  5.90nM ΔG°:  -11.2kcal/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  5.90nMAssay Description:Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  6.60nMAssay Description:Competitive inhibition of human recombinant AKR1C1 Phe311Ala mutant by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  7nMAssay Description:Competitive inhibition of human recombinant AKR1C1 Phe311Leu mutant by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1 [H222S](Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  58nM ΔG°:  -9.87kcal/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  70nM ΔG°:  -9.75kcal/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  70nMAssay Description:Inhibition of human AKR1C2 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1 [L54V](Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  85nM ΔG°:  -9.64kcal/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1 [L306A](Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  270nM ΔG°:  -8.95kcal/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1 [L308A](Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  2.80E+3nM ΔG°:  -7.57kcal/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  2.40E+4nM ΔG°:  -6.30kcal/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataKi:  9.40E+4nM ΔG°:  -5.49kcal/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of pig ALR1More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University

LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)
Affinity DataIC50:  6nMAssay Description:Inhibition of 20-alpha HSD (unknown origin)More data for this Ligand-Target Pair