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BDBM263152 US9708359, 108

SMILES: Cc1nc(N)c2c(cn([C@@H]3O[C@H](CN)[C@@H](O)[C@H]3O)c2n1)C(N)=O

InChI Key: InChIKey=XPNDSOHILHGMPC-ANBMGKIWNA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 263152   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Norovirus Polymerase


(Murine norovirus 1)
BDBM263152
PNG
(US9708359, 108)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CN)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1/C13H18N6O4/c1-4-17-10(15)7-5(11(16)22)3-19(12(7)18-4)13-9(21)8(20)6(2-14)23-13/h3,6,8-9,13,20-21H,2,14H2,1H3,(H2,16,22)(H2,15,17,18)/t6-,8-,9-,13-/s2
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair