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BDBM263257 US9708370, 68 ZS556::US9708370, ZS556

SMILES: C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1ccccc1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O

InChI Key: InChIKey=KXELJBCQQBNBNC-PLSWGINUNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263257   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet glycoprotein 4


(Rattus norvegicus)
BDBM263257
PNG
(US9708370, 68 ZS556 | US9708370, ZS556)
Show SMILES C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1ccccc1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1/C46H55N9O7/c1-30(50-44(60)40(27-34-28-49-37-17-9-8-16-36(34)37)51-41(57)24-21-31-12-4-2-5-13-31)43(59)54-55(29-33-19-22-35(56)23-20-33)46(62)53-39(26-32-14-6-3-7-15-32)45(61)52-38(42(48)58)18-10-11-25-47/h2-9,12-17,19-20,22-23,28,30,38-40,49,56H,10-11,18,21,24-27,29,47H2,1H3,(H2,48,58)(H,50,60)(H,51,57)(H,52,61)(H,53,62)(H,54,59)/t30-,38-,39+,40+/s2
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 3.25E+4n/an/an/an/a7.3n/a



VALORISATION-RECHERCHE, LIMITED PARTNERSHIP

US Patent


Assay Description
Competition experiments were performed by incubating 50 μg of LLC-PK1 membranes expressing human GHS-R1a with 15 fmol of 125I-Ghrelin and increa...


US Patent US9708370 (2017)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2XP76ZK
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM263257
PNG
(US9708370, 68 ZS556 | US9708370, ZS556)
Show SMILES C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1ccccc1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1/C46H55N9O7/c1-30(50-44(60)40(27-34-28-49-37-17-9-8-16-36(34)37)51-41(57)24-21-31-12-4-2-5-13-31)43(59)54-55(29-33-19-22-35(56)23-20-33)46(62)53-39(26-32-14-6-3-7-15-32)45(61)52-38(42(48)58)18-10-11-25-47/h2-9,12-17,19-20,22-23,28,30,38-40,49,56H,10-11,18,21,24-27,29,47H2,1H3,(H2,48,58)(H,50,60)(H,51,57)(H,52,61)(H,53,62)(H,54,59)/t30-,38-,39+,40+/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



VALORISATION-RECHERCHE, LIMITED PARTNERSHIP

US Patent


Assay Description
GHS-R1a radioreceptor assay using LLCPK-1 membranes overexpressing GSH-R1a and radioiodinated (1-28) rat ghrelin as tracer.


US Patent US9708370 (2017)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2XP76ZK
More data for this
Ligand-Target Pair