BDBM263303 1-(2-pyrazol-1-ylmethyl-thiazol-4-ylmethyl)-3-trifluoromethyl-1h-pyrazole-4-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide::US9533987, example 81

SMILES Nc1nccc2cc(CNC(=O)c3cn(Cc4csc(Cn5cccn5)n4)nc3C(F)(F)F)ccc12

InChI Key InChIKey=NTKGSHJOYRJNMU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263303   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263303(1-(2-pyrazol-1-ylmethyl-thiazol-4-ylmethyl)-3-trif...)
Affinity DataIC50:  8.97E+3nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263303(1-(2-pyrazol-1-ylmethyl-thiazol-4-ylmethyl)-3-trif...)
Affinity DataIC50:  26.5nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent