BDBM263457 (s)-2-(8-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-p-tolylethyl)acetamide::US10561662, Example 22::US11173161, EX 22::US9556130, test 22

SMILES C[C@H](NC(=O)Cn1nnc2c(Cl)cccc2c1=O)c1ccc(C)cc1

InChI Key InChIKey=ZXFHIAAKONRMNN-LBPRGKRZSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263457   

TargetProbable G-protein coupled receptor 139(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263457((s)-2-(8-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  110nM ΔG°:  -8.82kcal/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProbable G-protein coupled receptor 139(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263457((s)-2-(8-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  110nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProbable G-protein coupled receptor 139(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263457((s)-2-(8-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataKi:  1.10E+5nMAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent