BDBM263701 6-(3,4- dichloro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(3- chloro-2- fluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 38

SMILES Oc1ccc2c(CCCC(c3ccc(Cl)c(Cl)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1

InChI Key InChIKey=HTUALDBVBGCMRV-VWLOTQADSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263701   

TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263701(6-(3,4- dichloro- phenyl)-5-[4- [(3S)-1-(3- fluoro...)
Affinity DataIC50:  39nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263701(6-(3,4- dichloro- phenyl)-5-[4- [(3S)-1-(3- fluoro...)
Affinity DataIC50:  651nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [D538G](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263701(6-(3,4- dichloro- phenyl)-5-[4- [(3S)-1-(3- fluoro...)
Affinity DataIC50:  652nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent