BDBM264212 (2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl)amino] pyrimidin-4- yl}-1H-indol-7-yl)-2-(4- methylpiperazin-1- yl)propanamide::US10167276, Example 32::US10654835, Example 32::US11247983, Example 32::US20230416237, Example AZD4205::US9714236, 32

SMILES: COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12

InChI Key: InChIKey=CVCVOSPZEVINRM-UHFFFAOYSA-N

Data: 25 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 264212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 4B1 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	7.3	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [831-1132] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [831-1132] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	7.3	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [831-1132] (Human)	BDBM264212 ((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.47E+4	n/a	n/a	n/a	n/a	7.3	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair