BDBM264531 (7R)-7-[3,5- bis(trifluoromethyl)phenyl]- 4-{[4'-fluoro-2'-methoxy-5'- (1-methylethyl)-4- (trifluoromethyl)biphenyl-2- yl]methyl}-6-oxa-4- azaspiro[2.4]heptan-5-one::US9717714, 19

SMILES COc1cc(F)c(cc1-c1ccc(cc1CN1C(=O)O[C@H](c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CC1)C(F)(F)F)C(C)C

InChI Key InChIKey=MQUOQPJVFUUKOZ-AREMUKBSSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264531   

TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM264531((7R)-7-[3,5- bis(trifluoromethyl)phenyl]- 4-{[4'-f...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant CETP (unknown origin) assessed as inhibition of transfer of [3H]cholesteryl oleate or [3H]triolein between exogenous [3H]LD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM264531((7R)-7-[3,5- bis(trifluoromethyl)phenyl]- 4-{[4'-f...)
Affinity DataIC50:  361nMAssay Description:Transfer assays are performed in a 96-well v-bottom polypropylene plate. For the RTA using recombinant CETP (2% RTA), an assay cocktail is prepared w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent