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BDBM265146 US9718808, 9

SMILES: O=Cc1cnc(s1)-n1cnnn1

InChI Key: InChIKey=XSOKBFBWNQGLOD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 265146   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM265146
PNG
(US9718808, 9)
Show SMILES O=Cc1cnc(s1)-n1cnnn1
Show InChI InChI=1S/C5H3N5OS/c11-2-4-1-6-5(12-4)10-3-7-8-9-10/h1-3H
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 34n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ...


US Patent US9718808 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q2DJ5HNG
More data for this
Ligand-Target Pair