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BDBM26553 2-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}ethane-1-thiol::thiol-aryl sulfone, 8a

InChI string: InChI=1S/C12H14O3S2/c1-2-3-8-15-11-4-6-12(7-5-11)17(13,14)10-9-16/h4-7,16H,8-10H2,1H3

SMILES: CC#CCOc1ccc(cc1)S(=O)(=O)CCS

InChI Key: InChIKey=ARGOMDGUBFAFLZ-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26553   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TNF-alpha-Converting Enzyme


(Homo sapiens (human))
BDBM26553
PNG
(2-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}ethane-1-...)
Show SMILES CC#CCOc1ccc(cc1)S(=O)(=O)CCS
Show InChI InChI=1S/C12H14O3S2/c1-2-3-8-15-11-4-6-12(7-5-11)17(13,14)10-9-16/h4-7,16H,8-10H2,1H3
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
8 -10.9n/an/an/an/an/a7.522



Vertex Pharmaceuticals



Assay Description
The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...


Bioorg Med Chem Lett 18: 44-8 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)