BDBM26601 2-{3-[(5Z)-3-(carboxymethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetic acid::oxoindole-thioxothiazolidinone, 26

SMILES OC(=O)CN1C(=S)S\C(C1=O)=C1/C(=O)N(CC(O)=O)c2ccccc12

InChI Key InChIKey=RQSLTVUOPFHVJT-QXMHVHEDSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26601   

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
University Of Southern California

LigandPNGBDBM26601(2-{3-[(5Z)-3-(carboxymethyl)-4-oxo-2-sulfanylidene...)
Affinity DataIC50:  1.30E+4nMAssay Description:To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM26601(2-{3-[(5Z)-3-(carboxymethyl)-4-oxo-2-sulfanylidene...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of full-length microsomal PGES-1 (unknown origin) expressed in Escherichia coli Rosetta(DE3) using PGH2 as substrate assessed as inhibitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM26601(2-{3-[(5Z)-3-(carboxymethyl)-4-oxo-2-sulfanylidene...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of PGES-1 in human whole blood assessed as LPS-induced PGE2 formation incubated for 15 mins prior to LPS addition measured after 24 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed