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BDBM267010 US9718808, 139

SMILES: CN(C)C(=O)CN(Cc1ccc(nc1)-n1cnnn1)[C@H]1CC[C@]2(CCN(C3=C(C)C(=O)OC3)C2=O)CC1

InChI Key: InChIKey=UJGCILCVESUJIL-KJDSRRNHNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267010   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM267010
PNG
(US9718808, 139)
Show SMILES CN(C)C(=O)CN(Cc1ccc(nc1)-n1cnnn1)[C@H]1CC[C@]2(CCN(C3=C(C)C(=O)OC3)C2=O)CC1
Show InChI InChI=1/C25H32N8O4/c1-17-20(15-37-23(17)35)32-11-10-25(24(32)36)8-6-19(7-9-25)31(14-22(34)30(2)3)13-18-4-5-21(26-12-18)33-16-27-28-29-33/h4-5,12,16,19H,6-11,13-15H2,1-3H3/t19-,25+
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 120n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ...


US Patent US9718808 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q2DJ5HNG
More data for this
Ligand-Target Pair