BDBM267012 2-(3-(3-(2,2-dimethyl-3,6- dihydro-2H-pyran-4-yl)pyrazin- 2-yl)azetidin-1-yl)quinoline and 2-(3-(3-(6,6-dimethyl-3,6- dihydro-2H-pyran-4-yl)pyrazin- 2-yl)azetidin-1-yl)quinoline::US9718803, 4.42

SMILES CC1(C)OCCC(=C1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1

InChI Key InChIKey=PWPWFZAACFIVQT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267012   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM267012(2-(3-(3-(2,2-dimethyl-3,6- dihydro-2H-pyran-4-yl)p...)
Affinity DataIC50:  0.00100nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent