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BDBM267014 US9718808, 142

SMILES: CCN(Cc1ccc2C(=O)OCc2c1C)C1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1

InChI Key: InChIKey=IIPVMVNSURGBDA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267014   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM267014
PNG
(US9718808, 142)
Show SMILES CCN(Cc1ccc2C(=O)OCc2c1C)C1CCC2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1
Show InChI InChI=1S/C26H32N2O5/c1-4-27(13-18-5-6-20-21(16(18)2)14-32-24(20)30)19-7-9-26(10-8-19)11-12-28(25(26)31)22-15-33-23(29)17(22)3/h5-6,19H,4,7-15H2,1-3H3
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PC cid
PC sid
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Article
US Patent
n/an/a 490n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ...


US Patent US9718808 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q2DJ5HNG
More data for this
Ligand-Target Pair