BDBM267218 2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-[4-methyl(2H)-1,3-thiazol-5-yl]ethyl]-5-(5-fluoropyrimidin-2-yl)benzamide::US9718812, 69

SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1

InChI Key InChIKey=MKEXAUMSPHXNHF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267218   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM267218(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-[4-me...)
Affinity DataIC50:  98nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent