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BDBM267365 3-Chloro-5-[1-(2- dimethylamino-6-oxo- 1,6-dihydro-pyrimidin- 5-ylmethyl)-6-oxo-4- trifluoromethyl-1,6- dihydro-pyrimidin-5- yloxy]-benzonitrile::US10189831, Example 141::US9718819, 141

SMILES: CN(C)c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1

InChI Key: InChIKey=KIAYDRURGMZMQF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267365   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267365
PNG
(3-Chloro-5-[1-(2- dimethylamino-6-oxo- 1,6-dihydro...)
Show SMILES CN(C)c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C19H14ClF3N6O3/c1-28(2)18-25-7-11(16(30)27-18)8-29-9-26-15(19(21,22)23)14(17(29)31)32-13-4-10(6-24)3-12(20)5-13/h3-5,7,9H,8H2,1-2H3,(H,25,27,30)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 13n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US10189831 (2019)


Article DOI: 10.1021/jm049833g
BindingDB Entry DOI: 10.7270/Q2QF8VZJ
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM267365
PNG
(3-Chloro-5-[1-(2- dimethylamino-6-oxo- 1,6-dihydro...)
Show SMILES CN(C)c1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1
Show InChI InChI=1S/C19H14ClF3N6O3/c1-28(2)18-25-7-11(16(30)27-18)8-29-9-26-15(19(21,22)23)14(17(29)31)32-13-4-10(6-24)3-12(20)5-13/h3-5,7,9H,8H2,1-2H3,(H,25,27,30)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 13n/an/an/an/a7.825



Merck Sharp & Dohme Corp

US Patent


Assay Description
The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...


US Patent US9718819 (2017)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q2WM1GDF
More data for this
Ligand-Target Pair