BDBM267790 4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide::US9718828, Example, 396

SMILES: C[C@H]1CC[C@H](CN1C(=O)C1CC1)c1nc(-c2ccc(cc2F)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key: InChIKey=JUSWPUDQOKINJO-UHFFFAOYSA-N

Data: 28 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 267790   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein-tyrosine kinase 6 (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent L-type calcium channel subunit alpha-1C (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 5 subunit alpha (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Yes (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase TXK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Tec (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Srms (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ITK/TSK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	198	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase FRK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase CSK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	201	n/a	n/a	n/a	n/a	n/a	n/a
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Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM267790 (4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
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