BDBM269336 2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)-1-((1-(1-hydroxycyclopropanecarbonyl)azetidin-3-yl)methyl)-4,4-dimethyl-1H-imidazol-5(4H)-one ::US10413545, Compound 81::US9718813, Compound 81

SMILES Cn1cc(cn1)-c1ccc(cc1)-c1ccc(C2=NC(C)(C)C(=O)N2CC2CN(C2)C(=O)C2(O)CC2)c(F)c1

InChI Key InChIKey=NVZOSBFZBQAQJI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 269336   

TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269336(2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1'-bi...)
Affinity DataIC50:  525nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269336(2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1'-bi...)
Affinity DataIC50:  525nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target1,5-anhydro-D-fructose reductase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269336(2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1'-bi...)
Affinity DataIC50:  794nMpH: 7.5 T: 2°CAssay Description:10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent