BDBM26948 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL46516::FLUSPIRILENE::NCGC00015424::cid_3396::med.21724, Compound Fluspirilene::spiropiperidine analogue, 1

SMILES: Fc1ccc(cc1)C(CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1

InChI Key: InChIKey=QOYHHIBFXOOADH-UHFFFAOYSA-N

Data: 56 KI  5 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 65 hits for monomerid = 26948   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA damage-inducible transcript 3 protein (Mouse)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycine receptor subunit alpha-1 (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (SARS-CoV)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	5.96E+3	n/a	n/a	n/a	n/a
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Orf1a protein (MERS-CoV)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	7.47E+3	n/a	n/a	n/a	n/a
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Potassium channel subfamily K member 2 (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	232	n/a	n/a	7.3	22
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Arachidonate 15-lipoxygenase (Pseudomonas aeruginosa)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	25
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X-box-binding protein 1 (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
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DNA damage-inducible transcript 3 protein (Mouse)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(3) dopamine receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Bovine)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Bovine)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		0.670	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(3) dopamine receptor (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(4) dopamine receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(3) dopamine receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(3) dopamine receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent L-type calcium channel subunit alpha-1C (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(4) dopamine receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		8.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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5-hydroxytryptamine receptor 2A (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		9.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H1 receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-2B adrenergic receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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5-hydroxytryptamine receptor 1A (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-2C adrenergic receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		62	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Mu-type opioid receptor (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		77	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1A adrenergic receptor (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		102	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1A (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 10 subunit alpha (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Sigma non-opioid intracellular receptor 1 (Guinea pig)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2B (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		151	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(1A) dopamine receptor (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Nociceptin receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-2 adrenergic receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H1 receptor (Guinea pig)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		540	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-2A adrenergic receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		570	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-1 adrenergic receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		590	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Gastrin/cholecystokinin type B receptor (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium-dependent serotonin transporter (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Gamma-aminobutyric acid receptor subunit alpha-1 (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Thromboxane A2 receptor (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Protachykinin-1 (Human)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Cholecystokinin (Pig)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-arrestin-1 (Rabbit)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium-dependent dopamine transporter (Rat)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Kappa-type opioid receptor (Guinea pig)	BDBM26948 (CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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