BDBM269485 (S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-5-chloropicolinamide::US10058540, 1

SMILES NC1=N[C@](CF)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)C(F)(F)CC1

InChI Key InChIKey=MLHBJYSBEAENRB-QGZVFWFLSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 269485   

TargetBeta-secretase 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM269485( (S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2...)
Affinity DataKi:  5.70nM ΔG°:  -11.2kcal/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent