Molecular Structure for 27227

ARC-1028, 22 (2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}hexanamido)-N-(5-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}pentyl)hexanamide

Data: 2 IC50 2 Kd

Vconf -m prep

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits in this search
Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Protein kinase B (Akt 3) Homo sapiens (human)	ARC-1028, 22 ((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)	GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	14.6	n/a	n/a	7.5	30
Institute of Chemistry in Estonia		GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	J Med Chem. 52: 308-21 (2009)
cAMP-Dependent Protein Kinase (PKA) Mus musculus (mouse)	ARC-1028, 22 ((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	5.32	n/a	n/a	7.5	30
Institute of Chemistry in Estonia			PC cid PC sid	PubMed	J Med Chem. 52: 308-21 (2009)
cAMP-Dependent Protein Kinase (PKA) Mus musculus (mouse)	ARC-1028, 22 ((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt	PC cid PC sid	PubMed	n/a	n/a	n/a	<0.5	n/a	7.5	30
Institute of Chemistry in Estonia			PC cid PC sid	PubMed	J Med Chem. 52: 308-21 (2009)
Rho-kinase (ROCK II) Homo sapiens (human)	ARC-1028, 22 ((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	n/a	n/a	n/a	<1.0	n/a	7.5	30
Institute of Chemistry in Estonia		B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	J Med Chem. 52: 308-21 (2009)