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BDBM272899 (S)-2-((1-(2- aminobenzo[d]oxazol- 5-yl)-7,8,9,10- tetrahydro-6-oxa- 2,10a- diazacycloocta[cd]- inden-4- yl)oxy)propanamide::US10065970, Compound 204

SMILES: C\C=C(\O[C@@H](C)C(N)=O)/C=c1/nc(-c2ccc3oc(N)nc3c2)n2CCCCO/C=c/1\2

InChI Key: InChIKey=RJCFCNNTQDCDRA-GLFZUXCMNA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 272899   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM272899
PNG
((S)-2-((1-(2- aminobenzo[d]oxazol- 5-yl)-7,8,9,10-...)
Show SMILES C\C=C(\O[C@@H](C)C(N)=O)/C=c1/nc(-c2ccc3oc(N)nc3c2)n2CCCCO/C=c/1\2
Show InChI InChI=1/C22H25N5O4/c1-3-15(30-13(2)20(23)28)11-16-18-12-29-9-5-4-8-27(18)21(25-16)14-6-7-19-17(10-14)26-22(24)31-19/h3,6-7,10-13H,4-5,8-9H2,1-2H3,(H2,23,28)(H2,24,26)/b15-3+,16-11+,18-12-/t13-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
<0.0200n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
PI3K Binding assays are intended for determining the biochemical potency of small molecule PI3K inhibitors. The PI3K lipid kinase reaction is perform...


US Patent US10065970 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P91FB
More data for this
Ligand-Target Pair