BDBM273085 (R)-N-benzyl-1-[7-oxo-6-(tetrahydro-2H-pyran-4-yl)-5-trifluoromethyl-6,7-dihydro-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide::US10065972, Example 244

SMILES: FC(F)(F)c1nc2sc(nc2c(=O)n1C1CCOCC1)N1CCC[C@@H]1C(=O)NCc1ccccc1

InChI Key: InChIKey=JDHGHKDSRSZNSJ-MRXNPFEDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273085   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Homo sapiens (Human))	BDBM273085 ((R)-N-benzyl-1-[7-oxo-6-(tetrahydro-2H-pyran-4-yl)...) Show SMILES FC(F)(F)c1nc2sc(nc2c(=O)n1C1CCOCC1)N1CCC[C@@H]1C(=O)NCc1ccccc1 Show InChI InChI=1S/C23H24F3N5O3S/c24-23(25,26)21-29-19-17(20(33)31(21)15-8-11-34-12-9-15)28-22(35-19)30-10-4-7-16(30)18(32)27-13-14-5-2-1-3-6-14/h1-3,5-6,15-16H,4,7-13H2,(H,27,32)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	8.0	n/a
MITSUBISHI TANABE PHARMA CORPORATION US Patent					Assay Description The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...				US Patent US10065972 (2018) BindingDB Entry DOI: 10.7270/Q23X88P5
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