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BDBM275101 US10221195, Example 43::US9879032, Example 43

SMILES: COc1ccc(CO)cc1S(=O)(=O)Nc1cnc2OCC3(CC3)NC(=O)c2c1

InChI Key: InChIKey=NQQBUFNHJXWXDT-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275101   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM275101
PNG
(US10221195, Example 43 | US9879032, Example 43)
Show SMILES COc1ccc(CO)cc1S(=O)(=O)Nc1cnc2OCC3(CC3)NC(=O)c2c1
Show InChI InChI=1S/C18H19N3O6S/c1-26-14-3-2-11(9-22)6-15(14)28(24,25)21-12-7-13-16(23)20-18(4-5-18)10-27-17(13)19-8-12/h2-3,6-8,21-22H,4-5,9-10H2,1H3,(H,20,23)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US10221195 (2019)


Article DOI: 10.1016/j.bmcl.2007.06.023
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM275101
PNG
(US10221195, Example 43 | US9879032, Example 43)
Show SMILES COc1ccc(CO)cc1S(=O)(=O)Nc1cnc2OCC3(CC3)NC(=O)c2c1
Show InChI InChI=1S/C18H19N3O6S/c1-26-14-3-2-11(9-22)6-15(14)28(24,25)21-12-7-13-16(23)20-18(4-5-18)10-27-17(13)19-8-12/h2-3,6-8,21-22H,4-5,9-10H2,1H3,(H,20,23)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1n/an/an/an/an/a25



Daiichi Sankyo Company, Limited; Sandford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS 1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (In...


US Patent US9879032 (2018)


Article DOI: 10.1021/jm050483n
BindingDB Entry DOI: 10.7270/Q2F76FKB
More data for this
Ligand-Target Pair