BDBM27581 8-ethyl-8-[4-(phenoxymethyl)phenyl]-9-oxa-2,14-diazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaen-7-one::Pyrrolopyridooxazepinone (PPO), 6

SMILES CCC1(Oc2cccnc2-n2cccc2C1=O)c1ccc(COc2ccccc2)cc1

InChI Key InChIKey=IQCKIMSFZBKREW-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 27581   

TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Universita Di Siena

LigandPNGBDBM27581(8-ethyl-8-[4-(phenoxymethyl)phenyl]-9-oxa-2,14-dia...)
Affinity DataKi:  250nM ΔG°:  -9.36kcal/molepH: 7.5 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,K691N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Universita Di Siena

LigandPNGBDBM27581(8-ethyl-8-[4-(phenoxymethyl)phenyl]-9-oxa-2,14-dia...)
Affinity DataKi:  1.50E+3nM ΔG°:  -8.26kcal/molepH: 7.5 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,V694A]/[588-1147,V694A](Human immunodeficiency virus type 1)
Universita Di Siena

LigandPNGBDBM27581(8-ethyl-8-[4-(phenoxymethyl)phenyl]-9-oxa-2,14-dia...)
Affinity DataKi:  1.80E+3nMAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,V767D]/[588-1147,V767D](Human immunodeficiency virus type 1)
Universita Di Siena

LigandPNGBDBM27581(8-ethyl-8-[4-(phenoxymethyl)phenyl]-9-oxa-2,14-dia...)
Affinity DataKi:  3.60E+3nMAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,Y776L]/[588-1147,Y776L](Human immunodeficiency virus type 1)
Universita Di Siena

LigandPNGBDBM27581(8-ethyl-8-[4-(phenoxymethyl)phenyl]-9-oxa-2,14-dia...)
Affinity DataKi: <1.00E+4nMAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,Y769I]/[588-1147,Y769I](Human immunodeficiency virus type 1)
Universita Di Siena

LigandPNGBDBM27581(8-ethyl-8-[4-(phenoxymethyl)phenyl]-9-oxa-2,14-dia...)
Affinity DataKi: <1.00E+4nM ΔG°: <-7.09kcal/molepH: 7.5 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed