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BDBM275997 US10071974, Example 108::US10577336, Example 108

SMILES: Cc1cccn2c(cnc12)C(C)(C)NC(=O)[C@@H]1CNCCO1

InChI Key: InChIKey=IMGGSJYSCGDHAC-LBPRGKRZSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275997   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275997
PNG
(US10071974, Example 108 | US10577336, Example 108)
Show SMILES Cc1cccn2c(cnc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-13(10-18-14(11)20)16(2,3)19-15(21)12-9-17-6-8-22-12/h4-5,7,10,12,17H,6,8-9H2,1-3H3,(H,19,21)/t12-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 58.1n/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...


US Patent US10577336 (2020)


BindingDB Entry DOI: 10.7270/Q24F1T4F
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM275997
PNG
(US10071974, Example 108 | US10577336, Example 108)
Show SMILES Cc1cccn2c(cnc12)C(C)(C)NC(=O)[C@@H]1CNCCO1
Show InChI InChI=1S/C16H22N4O2/c1-11-5-4-7-20-13(10-18-14(11)20)16(2,3)19-15(21)12-9-17-6-8-22-12/h4-5,7,10,12,17H,6,8-9H2,1-3H3,(H,19,21)/t12-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 58.1n/an/a7.425



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...


US Patent US10071974 (2018)


BindingDB Entry DOI: 10.7270/Q28G8NQ7
More data for this
Ligand-Target Pair